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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RelM1Btlr
mutation 1, Bruce Beutler
MGI:5806335
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RelM1Btlr/RelM1Btlr C57BL/6J-RelM1Btlr MGI:5807165
ht2
 		RelM1Btlr/Rel+ C57BL/6J-RelM1Btlr MGI:5807166


Genotype
MGI:5807165
hm1
Allelic
Composition		 RelM1Btlr/RelM1Btlr
Genetic
Background		 C57BL/6J-RelM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelM1Btlr mutation (0 available); any Rel mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
decreased IgG level ( J:236682 )
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:236682 )
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

immune system
decreased IgE level ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
decreased IgG level ( J:236682 )
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:236682 )
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll
decreased response to antigen ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll




Genotype
MGI:5807166
ht2
Allelic
Composition		 RelM1Btlr/Rel+
Genetic
Background		 C57BL/6J-RelM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RelM1Btlr mutation (0 available); any Rel mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
decreased IgG level ( J:236682 )
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:236682 )
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

immune system
decreased IgE level ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
decreased IgG level ( J:236682 )
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:236682 )
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll
decreased response to antigen ( J:236682 )
• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide
• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory