About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprm7Btlr
mutation 7, Bruce Beutler
MGI:5806340
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Leprm7Btlr/Leprm7Btlr C57BL/6J-Leprm7Btlr MGI:5807180


Genotype
MGI:5807180
hm1
Allelic
Composition		 Leprm7Btlr/Leprm7Btlr
Genetic
Background		 C57BL/6J-Leprm7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprm7Btlr mutation (0 available); any Lepr mutation (122 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:236685 )
• increased levels of IgE levels in the peripheral blood
decreased response to antigen ( J:236685 )
• increased levels of IgE levels in the peripheral blood

homeostasis/metabolism
increased circulating glucose level ( J:236685 )
• increased blood glucose levels 30 minutes after glucose bolus

cellular
decreased cell death ( J:236685 )
• reduced killing of natural killer target cells

hematopoietic system
increased IgE level ( J:236685 )
• increased levels of IgE levels in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory