Phenotypes associated with this allele

• Allele Symbol: Sppl2a^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:5806433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sppl2a^m2Btlr/Sppl2a^m2Btlr	C57BL/6J-Sppl2a^m2Btlr	MGI:5807186

Genotype
MGI:5807186

hm1

• Allelic Composition: Sppl2a^m2Btlr/Sppl2a^m2Btlr
• Genetic Background: C57BL/6J-Sppl2a^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgG level ( J:236688 )

• reduced T-dependent antibody responses (IgG secretion) to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:236688 )

• reduced T-independent antibody response(IgM secretion) to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

decreased response to antigen ( J:236688 )

• reduced T-dependent antibody responses (IgG secretion) to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• reduced T-independent antibody response(IgM secretion) to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system

decreased IgG level ( J:236688 )

• reduced T-dependent antibody responses (IgG secretion) to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:236688 )

• reduced T-independent antibody response(IgM secretion) to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)