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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3cdm2Btlr
mutation 2, Bruce Beutler
MGI:5806440
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3cdm2Btlr/Pik3cdm2Btlr C57BL/6J-Pik3cdm2Btlr MGI:5807208
ht2
 		Pik3cdm2Btlr/Pik3cd+ C57BL/6J-Pik3cdm2Btlr MGI:5807209


Genotype
MGI:5807208
hm1
Allelic
Composition		 Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic
Background		 C57BL/6J-Pik3cdm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdm2Btlr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is reduced
increased circulating interferon-alpha level ( J:236693 )
• some mice show an increase in dsDNA induced type I IFN production in macrophages
increased susceptibility to Herpesvirales infection ( J:236693 )
• some mice show an increased proliferation of mouse cytomegalovirus (MCMV) in macrophages
decreased response to antigen ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is slightly diminished
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is slightly reduced
increased response to antigen ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE

homeostasis/metabolism
increased circulating interferon-alpha level ( J:236693 )
• some mice show an increase in dsDNA induced type I IFN production in macrophages

hematopoietic system
increased IgE level ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is reduced




Genotype
MGI:5807209
ht2
Allelic
Composition		 Pik3cdm2Btlr/Pik3cd+
Genetic
Background		 C57BL/6J-Pik3cdm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdm2Btlr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is slightly diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is slightly reduced
decreased response to antigen ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is slightly diminished
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is slightly reduced

hematopoietic system
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is slightly diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is slightly reduced




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory