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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifngr1m1Btlr
mutation 1, Bruce Beutler
MGI:5806453
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ifngr1m1Btlr/Ifngr1m1Btlr C57BL/6J-Ifngr1m1Btlr MGI:5807211


Genotype
MGI:5807211
hm1
Allelic
Composition		 Ifngr1m1Btlr/Ifngr1m1Btlr
Genetic
Background		 C57BL/6J-Ifngr1m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1m1Btlr mutation (0 available); any Ifngr1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:236694 )
• increased frequency of B cells, an increased IgD+ B cell percentage, an increased frequency of IgM+ B cells
decreased tumor necrosis factor secretion ( J:236694 )
• some mice also exhibit reduced TNF secretion from macrophages in response to the Toll-like receptor 3 (TLR3) ligand, poly(I:C), and priming with interferon (IFN)-

hematopoietic system
increased B cell number ( J:236694 )
• increased frequency of B cells, an increased IgD+ B cell percentage, an increased frequency of IgM+ B cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory