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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rcor2tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5806455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Emx1tm1(cre)Krj/Emx1+
Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
involves: 129S2/SvPas * C57BL/6N MGI:5897782
cn2
Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6N * SJL MGI:5897781


Genotype
MGI:5897782
cn1
Allelic
Composition
Emx1tm1(cre)Krj/Emx1+
Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Rcor2tm1c(EUCOMM)Wtsi mutation (0 available); any Rcor2 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E13.5 and E15.5




Genotype
MGI:5897781
cn2
Allelic
Composition
Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcor2tm1c(EUCOMM)Wtsi mutation (0 available); any Rcor2 mutation (39 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E13.5 and E15.5
• abnormalities in lamination at E15.5
• expression analysis indicates a dramatic decrease at E15.5
• cortical neural progenitor cells appear to exit the cell cycle earlier compared to controls
• cortical neural progenitor cells form smaller neurospheres in culture
• inhibition of SHH with Cyclopamine increases neurosphere size

cellular
• cortical neural progenitor cells appear to exit the cell cycle earlier compared to controls
• cortical neural progenitor cells form smaller neurospheres in culture
• inhibition of SHH with Cyclopamine increases neurosphere size





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory