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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dckm1Btlr
mutation 1, Bruce Beutler
MGI:5806456
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dckm1Btlr/Dckm1Btlr C57BL/6J-Dckm1Btlr MGI:5807216
ht2
 		Dckm1Btlr/Dck+ C57BL/6J-Dckm1Btlr MGI:5807217


Genotype
MGI:5807216
hm1
Allelic
Composition		 Dckm1Btlr/Dckm1Btlr
Genetic
Background		 C57BL/6J-Dckm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dckm1Btlr mutation (0 available); any Dck mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:236696 )
• decrease in B cell frequency, a decreased IgD+ B cell percentage, a reduced IgD mean fluorescence intensity (MFI) on B cells, and a decrease in IgM+ B cell frequency
increased IgE level ( J:236696 )
• in some mice
decreased IgG level ( J:236696 )
• T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) are diminished
decreased response to antigen ( J:236696 )
• T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) are diminished

hematopoietic system
decreased B cell number ( J:236696 )
• decrease in B cell frequency, a decreased IgD+ B cell percentage, a reduced IgD mean fluorescence intensity (MFI) on B cells, and a decrease in IgM+ B cell frequency
increased IgE level ( J:236696 )
• in some mice
decreased IgG level ( J:236696 )
• T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) are diminished




Genotype
MGI:5807217
ht2
Allelic
Composition		 Dckm1Btlr/Dck+
Genetic
Background		 C57BL/6J-Dckm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dckm1Btlr mutation (0 available); any Dck mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:236696 )
• slight decrease in B cell frequency, a slight decrease in the IgD+ B cell percentage, and a slight decrease in IgM+ B cell frequency

immune system
decreased B cell number ( J:236696 )
• slight decrease in B cell frequency, a slight decrease in the IgD+ B cell percentage, and a slight decrease in IgM+ B cell frequency




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory