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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tap1m2Btlr
mutation 2, Bruce Beutler
MGI:5806457
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tap1m2Btlr/Tap1m2Btlr C57BL/6J-Tap1m2Btlr MGI:5807245


Genotype
MGI:5807245
hm1
Allelic
Composition		 Tap1m2Btlr/Tap1m2Btlr
Genetic
Background		 C57BL/6J-Tap1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1m2Btlr mutation (0 available); any Tap1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:236697 )
• diminished frequency of CD8+ T cells, CD44+ T cells, CD44+ CD8+ T cells after MCMV infection
increased susceptibility to Herpesvirales infection ( J:236697 )
• increased mouse cytomegalovirus (MCMV) titer in the spleen five days after infection

hematopoietic system
impaired hematopoiesis ( J:236697 )
• after MCMV infection
decreased CD8-positive, alpha-beta T cell number ( J:236697 )
• diminished frequency of CD8+ T cells, CD44+ T cells, CD44+ CD8+ T cells after MCMV infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory