All Phenotypes Fnip1<m1Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fnip1^m1Btlr/Fnip1^m1Btlr	C57BL/6J-Fnip1^m1Btlr	MGI:5806736
cn2	Fnip1^m1Btlr/Fnip1^m1Btlr Prkag2^tm1.1Geno/Prkag2^tm1.1Geno Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:6116217
cn3	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5806734

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:234285 )

N	• mice exhibit normal left ventricle systolic function and corrected QT interval

increased cardiac muscle glycogen level ( J:234285 )

enlarged heart ( J:234285 )

cardiac hypertrophy ( J:234285 )

shortened PR interval ( J:234285 )

prolonged QRS complex duration ( J:234285 )

immune system

decreased marginal zone B cell number ( J:234285 )

• reduced marginal zone B cells and marginal zone precursor compartments

• however, transitional and follicular B cell subsets are normal

absent B cells ( J:234285 )

• in the peritoneum and spleen

• Tg(BCL2)25Wehi expression or Trp53^tm1Tyj deficiency does not correct peripheral B cell numbers

abnormal splenocyte morphology ( J:234285 )

• reduced frequency of IgM+ cells in B220+ splenocyte

decreased IgM level ( J:234285 )

• following immunization with the T cell-independent antigen NP28-aminoethyl carboxy-methyl-Ficoll (NP-Ficoll), mice exhibit a mild reduction in antigen-specific IgM compared with wild-type mice

cellular

enhanced autophagy ( J:234285 )

• increased autophagy in B cells

• however, Tg(BCL2)25Wehi expression reduces expression of the autophagy marker LC3

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:234285 )

enhanced autophagy ( J:234285 )

• increased autophagy in B cells

• however, Tg(BCL2)25Wehi expression reduces expression of the autophagy marker LC3

muscle

increased cardiac muscle glycogen level ( J:234285 )

abnormal skeletal muscle morphology ( J:234285 )

• darker in color than in wild-type mice

hematopoietic system

impaired hematopoiesis ( J:234285 )

• mice exhibit a cell-intrinsic failure of hematopoietic precursors to repopulate the CD19+ compartment compared with wild-type mice

abnormal bone marrow cell number ( J:234285 )

• absence of IgM+ or IgD+ cells

• however, B220 low B cell precursors are present

decreased marginal zone B cell number ( J:234285 )

• reduced marginal zone B cells and marginal zone precursor compartments

• however, transitional and follicular B cell subsets are normal

absent B cells ( J:234285 )

• in the peritoneum and spleen

• Tg(BCL2)25Wehi expression or Trp53^tm1Tyj deficiency does not correct peripheral B cell numbers

abnormal splenocyte morphology ( J:234285 )

• reduced frequency of IgM+ cells in B220+ splenocyte

decreased IgM level ( J:234285 )

• following immunization with the T cell-independent antigen NP28-aminoethyl carboxy-methyl-Ficoll (NP-Ficoll), mice exhibit a mild reduction in antigen-specific IgM compared with wild-type mice

growth/size/body

enlarged heart ( J:234285 )

cardiac hypertrophy ( J:234285 )

Allelic Composition	Fnip1^m1Btlr/Fnip1^m1Btlr Prkag2^tm1.1Geno/Prkag2^tm1.1Geno Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Fnip1^m1Btlr mutation (0 available); any Fnip1 mutation (60 available)
Prkag2^tm1.1Geno mutation (0 available); any Prkag2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:256296 )

N	• mice exhibit rescue of the bradycardia seen in single Fnip1 homozygotes

Allelic Composition	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3^tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Fnip1^m1Btlr mutation (0 available); any Fnip1 mutation (60 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

cellular

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

hematopoietic system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

homeostasis/metabolism

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24