Phenotypes associated with this allele

• Allele Symbol: Zranb1^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5806463
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zranb1^tm1d(EUCOMM)Hmgu/Zranb1^tm1d(EUCOMM)Hmgu	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N	MGI:5897849

Genotype
MGI:5897849

hm1

• Allelic Composition: Zranb1^{tm1d(EUCOMM)Hmgu}/Zranb1^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
• Cell Lines: HEPD0538_8_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:235701 )

N • mice exhibit normal frequencies of conventional dendritic cells and plasmacytoid dendritic cells in the bone marrow and spleen

decreased CD4-positive, alpha-beta T cell number ( J:235701 )

• moderate reduction in the frequency of naive T cells in the spleen

• however, regulatory T cell frequencies are normal

decreased T helper 1 cell number ( J:235701 )

• reduced frequency of IFNG+ Th1 cells in mice treated with MOG(35-55) along with pertussis toxin

• reduced frequency of Th1 cells in draining lymph nodes and spleen in mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• reduced frequency of IL17+Th17 cells in mice treated with MOG(35-55) along with pertussis toxin

• reduced frequency of Th17 cells in draining lymph nodes and spleen in mice treated with MOG(35-55) along with pertussis toxin

decreased circulating interferon-gamma level ( J:235701 )

• in mice treated with MOG(35-55) along with pertussis toxin

decreased circulating interleukin-17 level ( J:235701 )

• in mice treated with MOG(35-55) along with pertussis toxin

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:235701 )

• mice treated with MOG(35-55) along with pertussis toxin exhibit delayed onset, decreased clinical score and reduced inflammation compared with wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:235701 )

• in mice treated with MOG(35-55) along with pertussis toxin

decreased circulating interleukin-17 level ( J:235701 )

• in mice treated with MOG(35-55) along with pertussis toxin

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:235701 )

• moderate reduction in the frequency of naive T cells in the spleen

• however, regulatory T cell frequencies are normal

decreased T helper 1 cell number ( J:235701 )

• reduced frequency of IFNG+ Th1 cells in mice treated with MOG(35-55) along with pertussis toxin

• reduced frequency of Th1 cells in draining lymph nodes and spleen in mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• reduced frequency of IL17+Th17 cells in mice treated with MOG(35-55) along with pertussis toxin

• reduced frequency of Th17 cells in draining lymph nodes and spleen in mice treated with MOG(35-55) along with pertussis toxin