Phenotypes associated with this allele

• Allele Symbol: Cap2^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5806472
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cap2^tm1c(EUCOMM)Wtsi/Cap2^tm1c(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5806892
cn2	Cap2^tm1c(EUCOMM)Wtsi/Cap2^tm1c(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J * C57BL/6N	MGI:5806895

Genotype
MGI:5806892

hm1

• Allelic Composition: Cap2^{tm1c(EUCOMM)Wtsi}/Cap2^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:234044 )

♂ • males expressing full-length protein are born in higher numbers, do not develop eye infections, and do not die suddenly while isolated hearts appear normal

Genotype
MGI:5806895

cn2

• Allelic Composition: Cap2^{tm1c(EUCOMM)Wtsi}/Cap2^{tm1c(EUCOMM)Wtsi}; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

premature death ( J:234044 )

• males and females are born in equal numbers and appear healthy with no overt discomfort but exhibit sudden death by heart block between 12 and 24 weeks of age

• both males and females die at about the same age, indicating that there is no male bias in sudden death

cardiovascular system

cardiovascular system phenotype ( J:234044 )

N • at 12-20 weeks of age, no significant differences in left ventricular wall thickness, chamber size or function are observed in male or female mice relative to control mice

N • mice show no signs of increased interstitial fibrosis at ~15 weeks of age

decreased heart rate ( J:234044 )

• at 1 hour prior to death, mice exhibit a significantly lower heart rate than control mice

• average heart rate begins to drop at ~5 days prior to death

sinus bradycardia ( J:234044 )

• all (4 of 4) mice develop sinus bradycardia, unlike control mice which show no evidence of arrhythmias

abnormal impulse conducting system conduction ( J:234044 )

• at 12-20 weeks of age, mice show a significant increase in the AV Wenckebach cycle length relative to control mice

prolonged RR interval ( J:234044 )

• at 1 hour prior to death, mice show longer RR intervals than control mice

atrioventricular block ( J:234044 )

• all mice develop sinus bradycardia and die a few days later from complete atrioventricular block, unlike control mice which show no evidence of conduction defects or arrhythmias

prolonged HV interval ( J:234044 )

• at 12-20 weeks of age, mice show a significant increase in the HV-interval relative to control mice

prolonged QRS complex duration ( J:234044 )

• at 1 hour prior to death, mice show longer QRS intervals than control mice