Phenotypes associated with this allele

• Allele Symbol: Areg^{tm2c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5806473
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Areg^tm2c(EUCOMM)Hmgu/Areg^tm2c(EUCOMM)Hmgu Foxp3^tm4(YFP/icre)Ayr/Foxp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:5806476
cn2	Areg^tm2c(EUCOMM)Hmgu/Areg^tm2c(EUCOMM)Hmgu Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:5806477

Genotype
MGI:5806476

cn1

• Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu}; Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:224904 )

N • contrary to germ line deletion, mice are born in Mendelian ratios with no gender bias

immune system

immune system phenotype ( J:224904 )

N • mice exhibit normal frequencies and numbers of B and T cells and activated T cells

N • unchallenged mice exhibit no heightened inflammatory response and normal T regulator cell suppressor function

increased susceptibility to Orthomyxoviridae infection ( J:224904 )

• flu-infected mice exhibit a greater decrease in average blood oxygen saturation, overall lung tissue damage and decreased surface temperature compared with wild-type mice

• however, flu-infected mice exhibit normal T cell activation and T regulatory cell mediated suppression of anti-vial immunity

homeostasis/metabolism

decreased blood oxygen saturation level ( J:224904 )

• flu-infected mice exhibit a greater decrease in average blood oxygen saturation compared with wild-type mice

• however, mice do not exhibit anemia

decreased body surface temperature ( J:224904 )

• in flu-infected mice

• however, core body temperature is normal

Genotype
MGI:5806477

cn2

• Allelic Composition: Areg^{tm2c(EUCOMM)Hmgu}/Areg^{tm2c(EUCOMM)Hmgu}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

mortality/aging

mortality/aging ( J:224904 )

N • contrary to germ line deletion, mice are born in Mendelian ratios with no gender bias

immune system

immune system phenotype ( J:224904 )

N • mice exhibit normal frequencies and numbers of B and T cells and activated T cells

N • unchallenged mice exhibit no heightened inflammatory response and normal T regulator cell suppressor function

increased susceptibility to Orthomyxoviridae infection ( J:224904 )

• flu-infected mice exhibit a greater decrease in average blood oxygen saturation, overall lung tissue damage and decreased surface temperature compared with wild-type mice

• however, flu-infected mice exhibit normal T cell activation and T regulatory cell mediated suppression of anti-viral immunity

homeostasis/metabolism

decreased blood oxygen saturation level ( J:224904 )

• flu-infected mice exhibit a greater decrease in average blood oxygen saturation compared with wild-type mice

• however, mice do not exhibit anemia

decreased body surface temperature ( J:224904 )

• in flu-infected mice

• however, core body temperature is normal