Phenotypes associated with this allele

• Allele Symbol: Ddr2^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5806885
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ddr2^tm1c(EUCOMM)Wtsi/Ddr2^tm1c(EUCOMM)Wtsi Tg(KRT14-cre)1Amc/0 Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6 * C57BL/6N * CBA * FVB/N	MGI:5825268
cn2	Ddr2^tm1c(EUCOMM)Wtsi/Ddr2^tm1c(EUCOMM)Wtsi Tg(MMTV-cre)#Mam/0 Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6N * FVB * FVB/N	MGI:5825266

Genotype
MGI:5825268

cn1

• Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi}; Tg(KRT14-cre)1Amc/0; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors

decreased metastatic potential ( J:236031 )

• mice show a reduction in the number of lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

• in collagen I gels, a reduction in the number of invasive tumor organoids is seen

• however, in matrigel, tumor organoids show similar organoid budding and branching as single Tg(MMTV-PyVT)634Mul tumor organoids

integument

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors

Genotype
MGI:5825266

cn2

• Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi}; Tg(MMTV-cre)#Mam/0; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6N * FVB * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors

integument

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:236031 )

• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors