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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm4cGt(897)Tgen
gene trap 897, TransGenic
MGI:5806952
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm4cGt(897)Tgen/Kdm4cGt(897)Tgen B6.Cg-Kdm4cGt(897)Tgen MGI:5807098
ht2
 		Kdm4cGt(897)Tgen/Kdm4c+ B6.Cg-Kdm4cGt(897)Tgen MGI:5807099


Genotype
MGI:5807098
hm1
Allelic
Composition		 Kdm4cGt(897)Tgen/Kdm4cGt(897)Tgen
Genetic
Background		 B6.Cg-Kdm4cGt(897)Tgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4cGt(897)Tgen mutation (0 available); any Kdm4c mutation (371 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:227280 )
• no mice are obtained from breeding heterozygotes




Genotype
MGI:5807099
ht2
Allelic
Composition		 Kdm4cGt(897)Tgen/Kdm4c+
Genetic
Background		 B6.Cg-Kdm4cGt(897)Tgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4cGt(897)Tgen mutation (0 available); any Kdm4c mutation (371 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:227280 )
• in mice treated with DMBA and TPA

neoplasm
decreased incidence of tumors by chemical induction ( J:227280 )
• DMBA and TPA-treated mice exhibit fewer average number of papillomas and carcinomas with reduced carcinoma volume compared with wild-type mice
• however, the diameter of papillomas and incidence of carcinomas are the same as in wild-type mice

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:227280 )
• DMBA and TPA-treated mice exhibit fewer average number of papillomas and carcinomas with reduced carcinoma volume compared with wild-type mice
• however, the diameter of papillomas and incidence of carcinomas are the same as in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory