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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxnb2tm1.1Rkun
targeted mutation 1.1, Rohini Kuner
MGI:5807117
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pax8tm1.1(cre)Mbu/Pax8+
Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun 		involves: 129P2/OlaHsd * C57BL/6 MGI:5807121
cn2
 		Pax8tm1.1(cre)Mbu/Pax8+
Plxnb1tm1Rkun/Plxnb1tm1Rkun
Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun 		involves: 129P2/OlaHsd * C57BL/6 MGI:5807122


Genotype
MGI:5807121
cn1
Allelic
Composition		 Pax8tm1.1(cre)Mbu/Pax8+
Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax8tm1.1(cre)Mbu mutation (1 available); any Pax8 mutation (32 available)
Plxnb2tm1.1Rkun mutation (0 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to kidney reperfusion injury ( J:221423 )
• all tubules of the entire renal cortex and outer medulla show abnormal epithelial architecture after injury
• mice show no signs of recovery from induced bilateral kidney injury and become moribund 7 days after injury

renal/urinary system
increased susceptibility to kidney reperfusion injury ( J:221423 )
• mice show no signs of recovery from induced bilateral kidney injury and become moribund 7 days after injury
• all tubules of the entire renal cortex and outer medulla show abnormal epithelial architecture after injury
abnormal renal tubule epithelium morphology ( J:221423 )
• kidney histology during the acute organ damage 12 and 24 hours after ischemia/reperfusion injury is similar to wild-type mice, however 3 days after injury, renal tubular epithelial cells leave the epithelial plane and intrude into the tubular lumen which leads to a multi-layered epithelium and complete tubular occlusion by day 7
• renal tubular epithelial cells one day after injury exhibit a mitotic spindle angle that is shifted toward divisions perpendicular to the epithelial plane
• 3 days after kidney injury, a proportion of renal tubular epithelial cells fail to align their divisions with the epithelial plane
• however, kidney morphology and function are normal under basal conditions




Genotype
MGI:5807122
cn2
Allelic
Composition		 Pax8tm1.1(cre)Mbu/Pax8+
Plxnb1tm1Rkun/Plxnb1tm1Rkun
Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax8tm1.1(cre)Mbu mutation (1 available); any Pax8 mutation (32 available)
Plxnb1tm1Rkun mutation (0 available); any Plxnb1 mutation (108 available)
Plxnb2tm1.1Rkun mutation (0 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal tubule epithelium morphology ( J:221423 )
• mice exhibit foci of multi-layered tubules




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory