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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polr1atm1b(EUCOMM)Hmgu
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5810733
Summary 2 genotypes


Genotype
MGI:6263201
hm1
Allelic
Composition		 Polr1atm1b(EUCOMM)Hmgu/Polr1atm1b(EUCOMM)Hmgu
Genetic
Background		 C57BL/6N-Polr1atm1b(EUCOMM)Hmgu/Bay
Cell Lines HEPD0779_7_B03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1atm1b(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Polr1atm1b(EUCOMM)Hmgu/Polr1atm1b(EUCOMM)Hmgu mice exhibit embryonic lethality, with only 3% of embryos recovered at E3.5 as dying 2-cell stage embryos, suggesting zygotic genome activation failure.

embryo
abnormal preimplantation embryo development ( J:279207 )
• only dying 2-cell stage embryos are observed at E3.5, suggesting failure of zygotic genome activation
failure of blastocyst formation ( J:279207 )
• 2-cell stage embryos fail to reach a morphological blastocyst stage after 3 days in culture
embryonic growth arrest ( J:279207 )
• 2-cell stage embryos recovered at E3.5 appear to be dying
• in vitro, embryos show no further development after 3 days in culture

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• only a few homozygous embryos are recovered at E3.5 (3% versus expected 25%, n=36) and appear as dying 2-cell stage embryos; no embryos or excess resorption sites are observed at E7.5




Genotype
MGI:6288657
ht2
Allelic
Composition		 Polr1atm1b(EUCOMM)Hmgu/Polr1a+
Genetic
Background		 C57BL/6N-Polr1atm1b(EUCOMM)Hmgu/Bay
Cell Lines HEPD0779_7_B03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1atm1b(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory