Phenotypes associated with this allele

• Allele Symbol: Abcg8^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5810735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcg8^tm1b(KOMP)Wtsi/Abcg8^tm1b(KOMP)Wtsi	C57BL/6N-Abcg8^tm1b(KOMP)Wtsi/Ccpcz	MGI:6408220

Genotype
MGI:6408220

hm1

• Allelic Composition: Abcg8^{tm1b(KOMP)Wtsi}/Abcg8^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Abcg8^{tm1b(KOMP)Wtsi}/Ccpcz
• Cell Lines: EPD0270_5_F04

Data Sources

IMPC Data for Abcg8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:211773 )

♂

IMPC - CCP-IMG

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

IMPC - CCP-IMG

abnormal heart left ventricle morphology ( J:211773 )

IMPC - CCP-IMG

increased cardiac muscle contractility ( J:211773 )

IMPC - CCP-IMG

growth/size/body

enlarged liver ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

♀

IMPC - CCP-IMG

hematopoietic system

decreased hemoglobin content ( J:211773 )

♂

IMPC - CCP-IMG

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - CCP-IMG

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♀

IMPC - CCP-IMG

decreased mean corpuscular volume ( J:211773 )

♂

IMPC - CCP-IMG

increased red blood cell distribution width ( J:211773 )

IMPC - CCP-IMG

increased mean platelet volume ( J:211773 )

IMPC - CCP-IMG

decreased B-2 B cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

decreased NK T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD4-negative NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

♀

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - CCP-IMG

increased circulating triglyceride level ( J:211773 )

IMPC - CCP-IMG

decreased circulating iron level ( J:211773 )

♂

IMPC - CCP-IMG

increased circulating potassium level ( J:211773 )

♀

IMPC - CCP-IMG

decreased circulating sodium level ( J:211773 )

♂

IMPC - CCP-IMG

increased circulating alanine transaminase level ( J:211773 )

IMPC - CCP-IMG

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - CCP-IMG

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - CCP-IMG

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - CCP-IMG

abnormal cholesterol homeostasis ( J:211773 )

♀

IMPC - CCP-IMG

increased circulating cholesterol level ( J:211773 )

IMPC - CCP-IMG

immune system

immune system phenotype ( J:211773 )

IMPC - CCP-IMG

decreased B-2 B cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

decreased NK T cell number ( J:211773 )

IMPC - CCP-IMG

decreased CD4-negative NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

♀

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - CCP-IMG

enlarged liver ( J:211773 )

IMPC - CCP-IMG

muscle

increased cardiac muscle contractility ( J:211773 )

IMPC - CCP-IMG

reproductive system

female infertility ( J:211773 )

♀

IMPC - CCP-IMG

male infertility ( J:211773 )

♂

IMPC - CCP-IMG

respiratory system

increased lung elastance ( J:211773 )

♀

IMPC - CCP-IMG

decreased lung compliance ( J:211773 )

♀

IMPC - CCP-IMG

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

IMPC - CCP-IMG

abnormal lens morphology ( J:211773 )

♀

IMPC - CCP-IMG

cataract ( J:211773 )

IMPC - CCP-IMG