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Allele Symbol Allele Name Allele ID |
RhoTvrm334 translational research vision model 334 MGI:5810761 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more rapid degeneration than in heterozygotes
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• more rapid degeneration than in heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells
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• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells
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• although light adapted (cone) ERG readings are normal at 21 days of age, dark-adapted ERG shows severely diminished rod function
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 4 | DOID:0110372 |
OMIM:613731 |
J:243745 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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