About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alms1tvrm102
translational vision research model 102
MGI:5810779
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Alms1tvrm102/Alms1tvrm102 C57BL/6J-Alms1tvrm102/Pjn MGI:5924963
ht2
 		Alms1tvrm102/Alms1Gt(XH152)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:5925409


Genotype
MGI:5924963
hm1
Allelic
Composition		 Alms1tvrm102/Alms1tvrm102
Genetic
Background		 C57BL/6J-Alms1tvrm102/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1tvrm102 mutation (1 available); any Alms1 mutation (150 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
retina pigment epithelium atrophy ( J:243745 )
• by 5 months of age fundus images have a grainy appearance with atypical retinal pigment epithelium and by 15 months of age small bright spots are found

growth/size/body
obese ( J:243745 )
• between 6 and 12 weeks of age males begin to show increased weight relative to controls and they average over 40g at 20 weeks of age

nervous system

vision/eye
retina pigment epithelium atrophy ( J:243745 )
• by 5 months of age fundus images have a grainy appearance with atypical retinal pigment epithelium and by 15 months of age small bright spots are found
retina outer nuclear layer degeneration ( J:243745 )
• marginal thinning of the outer nuclear layer at 5 months of age and by 18 months only approximately 25% of photoreceptors remain
increased susceptibility to age-related retinal degeneration ( J:243745 )
• slow, progressive retinal degeneration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alstrom syndrome DOID:0050473 OMIM:203800
 J:243745




Genotype
MGI:5925409
ht2
Allelic
Composition		 Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1Gt(XH152)Byg mutation (0 available); any Alms1 mutation (150 available)
Alms1tvrm102 mutation (1 available); any Alms1 mutation (150 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:243745 )

nervous system

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory