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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alms1tvrm102
translational vision research model 102
MGI:5810779
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Alms1tvrm102/Alms1tvrm102 C57BL/6J-Alms1tvrm102/Pjn MGI:5924963
ht2
 		Alms1tvrm102/Alms1Gt(XH152)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:5925409


Genotype
MGI:5924963
hm1
Allelic
Composition		 Alms1tvrm102/Alms1tvrm102
Genetic
Background		 C57BL/6J-Alms1tvrm102/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1tvrm102 mutation (1 available); any Alms1 mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
retina pigment epithelium atrophy ( J:243745 )
• by 5 months of age fundus images have a grainy appearance with atypical retinal pigment epithelium and by 15 months of age small bright spots are found

growth/size/body
obese ( J:243745 )
• between 6 and 12 weeks of age males begin to show increased weight relative to controls and they average over 40g at 20 weeks of age

nervous system

vision/eye
retina pigment epithelium atrophy ( J:243745 )
• by 5 months of age fundus images have a grainy appearance with atypical retinal pigment epithelium and by 15 months of age small bright spots are found
retina outer nuclear layer degeneration ( J:243745 )
• marginal thinning of the outer nuclear layer at 5 months of age and by 18 months only approximately 25% of photoreceptors remain
increased susceptibility to age-related retinal degeneration ( J:243745 )
• slow, progressive retinal degeneration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alstrom syndrome DOID:0050473 OMIM:203800
 J:243745




Genotype
MGI:5925409
ht2
Allelic
Composition		 Alms1tvrm102/Alms1Gt(XH152)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1Gt(XH152)Byg mutation (0 available); any Alms1 mutation (151 available)
Alms1tvrm102 mutation (1 available); any Alms1 mutation (151 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:243745 )

nervous system

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory