Phenotypes associated with this allele

• Allele Symbol: Cdc14a^em1Tbf
• Allele Name: endonuclease-mediated mutation 1, Thomas B Friedman
• Allele ID: MGI:5810960
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc14a^em1Tbf/Cdc14a^em1Tbf	involves: C57BL/6J	MGI:6694869

Genotype
MGI:6694869

hm1

• Allelic Composition: Cdc14a^em1Tbf/Cdc14a^em1Tbf
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:257652 )

• crosses between heterozygotes yield only 5 survivors out of 153 progeny

hearing/vestibular/ear

fused inner hair cell stereocilia ( J:257652 )

• fusion of stereocilia at P60

fused outer hair cell stereocilia ( J:257652 )

• fusion of stereocilia at P60

cochlear hair cell degeneration ( J:257652 )

• degeneration of hair cells at P60

deafness ( J:257652 )

• mice are severely to profoundly deaf at P60

reproductive system

oligozoospermia ( J:257652 )

♂ • low sperm counts

seminiferous tubule degeneration ( J:257652 )

♂

male infertility ( J:257652 )

♂

nervous system

fused inner hair cell stereocilia ( J:257652 )

• fusion of stereocilia at P60

fused outer hair cell stereocilia ( J:257652 )

• fusion of stereocilia at P60

cochlear hair cell degeneration ( J:257652 )

• degeneration of hair cells at P60

cellular

oligozoospermia ( J:257652 )

♂ • low sperm counts

endocrine/exocrine glands

seminiferous tubule degeneration ( J:257652 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive nonsyndromic deafness 32		DOID:0110491	OMIM:608653	J:257652