Phenotypes associated with this allele

• Allele Symbol: Camk2a^em1Rjco
• Allele Name: endonuclease-mediated mutation 1, Roger J Colbran
• Allele ID: MGI:5811610
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^em1Rjco/Camk2a^em1Rjco	involves: C57BL/6J * DBA/2J	MGI:6324924
ht2	Camk2a^em1Rjco/Camk2a^+	involves: C57BL/6J * DBA/2J	MGI:6324926

Genotype
MGI:6324924

hm1

• Allelic Composition: Camk2a^em1Rjco/Camk2a^em1Rjco
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:239596 )

• mice exhibit decreased marble burying behavior, suggesting reduced exploration in a complex environment

increased thigmotaxis ( J:239596 )

• mice spend less time in the center of the open field arena than wild-type mice, indicating increased anxiety

hyperactivity ( J:239596 )

• mice are hyperactive in a novel open field arena

increased vertical activity ( J:239596 )

• mice exhibit increased rearing and jumping in the open field and these behaviors are persistent across the entire test period, indicating repetitive behavior

circling ( J:239596 )

• mice exhibit increased repetitive rotational behavior in the 3-chamber social assay

abnormal social/conspecific interaction behavior ( J:239596 )

• mice exhibit a deficit in social motivation as indicated by increased circling in the 3-chamber social assay

• however, no deficits in preference for social novelty is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:239596

Genotype
MGI:6324926

ht2

• Allelic Composition: Camk2a^em1Rjco/Camk2a⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

behavior/neurological

decreased exploration in new environment ( J:239596 )

• mice exhibit decreased marble burying behavior, suggesting reduced exploration in a complex environment

increased thigmotaxis ( J:239596 )

• mice spend less time in the center of the open field arena than wild-type mice, indicating increased anxiety

abnormal response to social novelty ( J:239596 )

• mice show no preference for a novel mouse versus familiar mouse in the 3-chamber test, indicating deficits in social memory or preference for social novelty