Phenotypes associated with this allele

• Allele Symbol: Arid3b^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5812005
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arid3b^tm1c(KOMP)Wtsi/Arid3b^tm1c(KOMP)Wtsi Tg(Mx1-cre)1Cgn/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:5819087

Genotype
MGI:5819087

cn1

• Allelic Composition: Arid3b^{tm1c(KOMP)Wtsi}/Arid3b^{tm1c(KOMP)Wtsi}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:236980 )

N • pIpC-treated mice show normal erythroid and myeloid development and no changes in the hematopoietic stem cell (HSC) population relative to controls

N • no differences in the common myeloid progenitor population (CMP) or the downstream granulocyte/monocyte progenitor (GMP) and megakaryocyte/erythroid progenitor (MEP) populations are observed

N • B cells produce normal serum IgG levels and are able to proliferate normally and differentiate into plasma cells during ex vivo culture upon LPS stimulation

abnormal B cell differentiation ( J:236980 )

• pIpC-treated mice show reduced formation of early B cell progenitors in the bone marrow

• ex vivo, Lin- cells co-cultured with OP9 stromal cells in the presence of IL7 and Flt3L (to promote B cell development) do not exhibit any B220+ B cell growth, suggesting that stem cells fail to differentiate into committed progenitor B cells

decreased immature B cell number ( J:236980 )

• pIpC-treated mice show decreased immature B cell populations in the bone marrow

• however, mature recirculating B cell numbers are normal

decreased transitional stage B cell number ( J:236980 )

• pIpC-treated mice show a significant decrease in the transitional T1-T2 cell population in the spleen

decreased pro-B cell number ( J:236980 )

• pIpC-treated mice show decreased pro-B cell populations in the bone marrow

decreased pre-pro B cell number ( J:236980 )

• pIpC-treated mice show decreased pre-pro B cell populations in the bone marrow

decreased common lymphocyte progenitor cell number ( J:236980 )

• pIpC-treated mice show ~2 fold reduction in the common lymphocyte progenitor (CLP) population in the bone marrow

• most of this reduction is due to reduced B cell biased lymphoid progenitor (BLP) numbers

• all lymphoid progenitor (ALP) numbers are only modesty reduced

increased B-1a cell number ( J:236980 )

• pIpC-treated mice show a modest increase of B-1a cells in the peritoneal cavity

• however, B2 cell numbers are normal

increased follicular B cell number ( J:236980 )

• pIpC-treated mice show a significant increase in the follicular zone population in spleen

decreased B cell number ( J:236980 )

• pIpC-treated mice show a 2-fold decrease in B (B220+) cells in the bone marrow

• analysis of B cell populations using Hardy fraction cell surface markers (B220, CD43, BP-1, HSA, IgM, and IgD) showed significant decreases in all B cell populations, except for the C population

• mature/recirculating B cells (fraction F) are only modestly reduced

decreased B-1b cell number ( J:236980 )

• pIpC-treated mice show a modest decrease of B-1b cells in the peritoneal cavity

decreased pre-B cell number ( J:236980 )

• pIpC-treated mice show decreased pre-pro B cell populations in the bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:236980 )

• pIpC-treated mice show a modest but significant decrease of CD4+ T cells in the thymus

• thymic double positive (CD4+ CD8+) cells and single CD8+ T cell populations are normal

• no significant differences are observed in splenic CD4+ and CD8+ T cell populations

immune system

abnormal B cell differentiation ( J:236980 )

• pIpC-treated mice show reduced formation of early B cell progenitors in the bone marrow

• ex vivo, Lin- cells co-cultured with OP9 stromal cells in the presence of IL7 and Flt3L (to promote B cell development) do not exhibit any B220+ B cell growth, suggesting that stem cells fail to differentiate into committed progenitor B cells

decreased immature B cell number ( J:236980 )

• pIpC-treated mice show decreased immature B cell populations in the bone marrow

• however, mature recirculating B cell numbers are normal

decreased transitional stage B cell number ( J:236980 )

• pIpC-treated mice show a significant decrease in the transitional T1-T2 cell population in the spleen

decreased pro-B cell number ( J:236980 )

• pIpC-treated mice show decreased pro-B cell populations in the bone marrow

decreased pre-pro B cell number ( J:236980 )

• pIpC-treated mice show decreased pre-pro B cell populations in the bone marrow

increased B-1a cell number ( J:236980 )

• pIpC-treated mice show a modest increase of B-1a cells in the peritoneal cavity

• however, B2 cell numbers are normal

increased follicular B cell number ( J:236980 )

• pIpC-treated mice show a significant increase in the follicular zone population in spleen

decreased B cell number ( J:236980 )

• pIpC-treated mice show a 2-fold decrease in B (B220+) cells in the bone marrow

• analysis of B cell populations using Hardy fraction cell surface markers (B220, CD43, BP-1, HSA, IgM, and IgD) showed significant decreases in all B cell populations, except for the C population

• mature/recirculating B cells (fraction F) are only modestly reduced

decreased B-1b cell number ( J:236980 )

• pIpC-treated mice show a modest decrease of B-1b cells in the peritoneal cavity

decreased pre-B cell number ( J:236980 )

• pIpC-treated mice show decreased pre-pro B cell populations in the bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:236980 )

• pIpC-treated mice show a modest but significant decrease of CD4+ T cells in the thymus

• thymic double positive (CD4+ CD8+) cells and single CD8+ T cell populations are normal

• no significant differences are observed in splenic CD4+ and CD8+ T cell populations