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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Malt1tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5812177
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT5-cre)5132Jlj/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J MGI:6460070
cn2
 		Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT14-cre/ERT)20Efu/0 		involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 MGI:6460074


Genotype
MGI:6460070
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (1006 available)
Malt1tm1c(EUCOMM)Hmgu mutation (0 available); any Malt1 mutation (35 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:292094 )
N
• mice exhibit normal postnatal survival




Genotype
MGI:6460074
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (1006 available)
Malt1tm1c(EUCOMM)Hmgu mutation (0 available); any Malt1 mutation (35 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin inflammation ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
thick epidermis ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
psoriasis ( J:292094 )
• from 6 weeks on, mice exhibit mild ear thickening unlike control mice
• tamoxifen-treated mice exhibit increased ear swelling that is not as severe as in mice with wild-type Matl1

immune system
increased neutrophil cell number ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
increased dendritic cell number ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
skin inflammation ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

growth/size/body
decreased body weight ( J:292094 )
• in tamoxifen-treated that is not as severe as in mice with wild-type Matl1

hematopoietic system
increased neutrophil cell number ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
increased dendritic cell number ( J:292094 )
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory