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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm2(ATF4)Myz
targeted mutation 2, Makoto Miyazaki
MGI:5812282
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz
Tg(Myh11-icre/ERT2)1Soff/?
either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff MGI:5812901


Genotype
MGI:5812901
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz
Tg(Myh11-icre/ERT2)1Soff/?
Genetic
Background
either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(ATF4)Myz mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• following administration of tamoxifen, mice develop severe medial calcification in aortic sinuses

cellular
• following administration of tamoxifen, there is an increase of apoptotic cells in the aorta

homeostasis/metabolism
N
• following administration of tamoxifen, levels of phosphorus, calcium, cholesterol and triglyceride are similar to controls

muscle
• following administration of tamoxifen, there is an increase of apoptotic cells in the aorta





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory