Phenotypes associated with this allele

• Allele Symbol: Map3k12^tm1Lbh
• Allele Name: targeted mutation 1, Lawrence B Holzman
• Allele ID: MGI:5812286
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k12^tm1Lbh/Map3k12^tm1Lbh	Not Specified	MGI:6780147

Genotype
MGI:6780147

cn1

• Allelic Composition: Map3k12^tm1Lbh/Map3k12^tm1Lbh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:236918 )

• primary cerebellar granule neurons (CGNs) purified from mutant mice and infected with AAV-GFP-Cre show impaired c-Jun N-terminal kinase (JNK) activation by 5 days in vitro (DIV)

abnormal axon extension ( J:236918 )

• in vitro, CGNs isolated from P7 mutant mice and co-transfected with pMAX-GFP and pCAG-Cre (to generate GFP-labeled Map3k12 knockout CGNs) show a ~10-25% reduction in axon growth

• however, no effect on branching or total number of neurites is observed

nervous system

abnormal axon extension ( J:236918 )

• in vitro, CGNs isolated from P7 mutant mice and co-transfected with pMAX-GFP and pCAG-Cre (to generate GFP-labeled Map3k12 knockout CGNs) show a ~10-25% reduction in axon growth

• however, no effect on branching or total number of neurites is observed