Phenotypes associated with this allele

• Allele Symbol: vtab
• Allele Name: variable tail abnormalities
• Allele ID: MGI:5812896
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	vtab/vtab	CBy.Cg-vtab/GrsrJ	MGI:5812912

Genotype
MGI:5812912

hm1

• Allelic Composition: vtab/vtab
• Genetic Background: CBy.Cg-vtab/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased male germ cell number ( J:237551 )

♂

limbs/digits/tail

kinked tail ( J:237551 )

• variable tail kinks and bends, with some only discernable by palpation

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:237551 )

♂ • segmental tubular degeneration and atrophy in the testes of two 28-week-old homozygotes

seminiferous tubule degeneration ( J:237551 )

♂

mortality/aging

prenatal lethality, incomplete penetrance ( J:237551 )

• heterozygous intercrosses yielded only approximately 10% homozygotes and homozygote x heterozygote intercrosses yielded approximately 11% homzygotes indicative of prenatal lethality

reproductive system

decreased male germ cell number ( J:237551 )

♂

abnormal seminiferous tubule morphology ( J:237551 )

♂ • segmental tubular degeneration and atrophy in the testes of two 28-week-old homozygotes

seminiferous tubule degeneration ( J:237551 )

♂

abnormal spermiogenesis ( J:237551 )

♂ • histology indicates reduced spermiogenesis and evidence of germ cell depletion