Phenotypes associated with this allele

• Allele Symbol: Dbnl^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5812932
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbnl^tm1b(KOMP)Wtsi/Dbnl^tm1b(KOMP)Wtsi	C57BL/6N-Dbnl^tm1b(KOMP)Wtsi/Orl	MGI:6408326

Genotype
MGI:6408326

hm1

• Allelic Composition: Dbnl^{tm1b(KOMP)Wtsi}/Dbnl^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dbnl^{tm1b(KOMP)Wtsi}/Orl
• Cell Lines: EPD0504_4_A04

Data Sources

IMPC Data for Dbnl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased fluid intake ( J:211773 )

♂

IMPC - ICS

increased startle reflex ( J:211773 )

♀

IMPC - ICS

increased grip strength ( J:211773 )

♀

IMPC - ICS

decreased locomotor activity ( J:211773 )

♀

IMPC - ICS

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

IMPC - ICS

increased heart weight ( J:211773 )

♀

IMPC - ICS

growth/size/body

increased heart weight ( J:211773 )

♀

IMPC - ICS

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - ICS

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - ICS

decreased hematocrit ( J:211773 )

IMPC - ICS

decreased hemoglobin content ( J:211773 )

♂

IMPC - ICS

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - ICS

increased mean corpuscular volume ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased circulating glucose level ( J:211773 )

IMPC - ICS

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - ICS

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - ICS

decreased circulating triglyceride level ( J:211773 )

IMPC - ICS

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - ICS

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - ICS

decreased circulating total protein level ( J:211773 )

♂

IMPC - ICS

nervous system

abnormal optic disk morphology ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina vasculature morphology ( J:211773 )

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

IMPC - ICS

abnormal optic disk morphology ( J:211773 )

♂

IMPC - ICS

persistence of hyaloid vascular system ( J:211773 )

IMPC - ICS

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - ICS

decreased total retina thickness ( J:211773 )

♀

IMPC - ICS