All Phenotypes Rai1<tm2.1Luo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rai1^tm2.1Luo
targeted mutation 2.1, Liqun Luo
MGI:5816464

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/? Rai1^tm2.1Luo/Rai1^tm2.1Luo	either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)	MGI:5817664
cn2	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)	MGI:5817645
cn3	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817637
cn4	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)	MGI:5817641
cn5	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Gfap-cre)73.12Mvs/?	either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)	MGI:5817666
cn6	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nr5a1-cre)7Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817657
cn7	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817650
cn8	Rai1^tm2.1Luo/Rai1⁺ Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817653
cn9	Rai1^tm2.1Luo/Rai1⁺ Tg(Nr5a1-cre)7Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817661
cn10	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817471
cn11	Rai1^tm2.1Luo/Rai1⁺ Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817609
cn12	Rai1^tm2.2Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)	MGI:5817614

Allelic Composition	Emx1^tm1(cre)Krj/? Rai1^tm2.1Luo/Rai1^tm2.1Luo
Genetic Background	either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:237687 )

• mice do not exhibit differences in behavior, motor function or body weight from controls

Allelic Composition	Gad2^tm2(cre)Zjh/? Rai1^tm2.1Luo/Rai1^tm2.1Luo
Genetic Background	either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2^tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual memory recall

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

impaired coordination ( J:237687 )

• increased time required to descend in pole test

• increased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• increased latency to fall in wire hang test

growth/size/body

increased body weight ( J:237687 )

• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Gfap-cre)73.12Mvs/?
Genetic Background	either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Gfap-cre)73.12Mvs mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:237687 )

• mice do not exhibit differences in behavior, motor function or body weight

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nr5a1-cre)7Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males exhibit no motor weakness in wire hang test

growth/size/body

increased body weight ( J:237687 )

• females are 27% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:237687 )

increased total fat pad weight ( J:237687 )

• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males exhibit no motor weakness in wire hang test

polyphagia ( J:237687 )

• hyperphagic with a 47% increase in average daily food intake

decreased locomotor activity ( J:237687 )

• decreased horizontal locomotor activity

growth/size/body

increased body fat mass ( J:237687 )

increased lean body mass ( J:237687 )

obese ( J:237687 )

• mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism

increased cholesterol level ( J:237687 )

increased circulating HDL cholesterol level ( J:237687 )

increased circulating LDL cholesterol level ( J:237687 )

increased circulating VLDL cholesterol level ( J:237687 )

increased triglyceride level ( J:237687 )

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Sim1-cre)1Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:237687 )

• females are 12.7% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Nr5a1-cre)7Lowl/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:237687 )

• females are 27% heavier than controls at 20 weeks of age

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237687 )

N	• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition • males have normal hearing and pain responses

abnormal associative learning ( J:237687 )

• decreased freezing behavior after repeated tone-shock pairings during training

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

abnormal spatial working memory ( J:237687 )

• reduced tendency to explore new arm in Y maze

limb grasping ( J:237687 )

• hindlimb clasping

impaired coordination ( J:237687 )

• in pole test males slip from pole or climb down in a slow and uncoordinated fashion

• decreased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 5 weeks of age

• at 20 weeks female mice are 101% heavier than controls

decreased body size ( J:237687 )

• mice are smaller than littermates prior to weaning

mortality/aging

premature death ( J:237687 )

• more than 80% of mice die before 25 weeks of age

skeleton

kyphosis ( J:237687 )

• kyphosis in 10% of mice that die before 10 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Smith-Magenis syndrome		DOID:0060768	OMIM:182290	J:237687

Allelic Composition	Rai1^tm2.1Luo/Rai1⁺ Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:237687 )

• males exhibit a decreased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 7 weeks of age

• at 20 weeks female mice are 35% heavier than controls

Allelic Composition	Rai1^tm2.2Luo/Rai1^tm2.1Luo Tg(Nes-cre)1Kln/?
Genetic Background	either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Rai1^tm2.2Luo mutation (0 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:237687 )

• female mice become overweight beginning at 7 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24