normal phenotype
• mice do not exhibit differences in behavior, motor function or body weight from controls
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Allele Symbol Allele Name Allele ID |
Rai1tm2.1Luo targeted mutation 2.1, Liqun Luo MGI:5816464 |
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Summary |
12 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice do not exhibit differences in behavior, motor function or body weight from controls
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• decreased freezing behavior in contextual memory recall
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• decreased freezing behavior in cued recall
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• decreased freezing behavior in contextual recall in trace fear-conditioning task
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• decreased freezing behavior in cued recall
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• increased time required to descend in pole test
• increased latency to fall in wire hang test
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• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• increased latency to fall in wire hang test
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• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice do not exhibit differences in behavior, motor function or body weight
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• males exhibit no motor weakness in wire hang test
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• females are 27% heavier than controls at 20 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT
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N |
• males exhibit no motor weakness in wire hang test
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• hyperphagic with a 47% increase in average daily food intake
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• decreased horizontal locomotor activity
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• females are 12.7% heavier than controls at 20 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• females are 27% heavier than controls at 20 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition
• males have normal hearing and pain responses
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• decreased freezing behavior after repeated tone-shock pairings during training
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• decreased freezing behavior in contextual recall in trace fear-conditioning task
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• decreased freezing behavior in cued recall
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• reduced tendency to explore new arm in Y maze
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• hindlimb clasping
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• in pole test males slip from pole or climb down in a slow and uncoordinated fashion
• decreased latency to fall in wire hang test
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• female mice become overweight beginning at 5 weeks of age
• at 20 weeks female mice are 101% heavier than controls
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• mice are smaller than littermates prior to weaning
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• more than 80% of mice die before 25 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Smith-Magenis syndrome | DOID:0060768 |
OMIM:182290 |
J:237687 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• males exhibit a decreased latency to fall in wire hang test
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• female mice become overweight beginning at 7 weeks of age
• at 20 weeks female mice are 35% heavier than controls
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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