About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rai1tm2.1Luo
targeted mutation 2.1, Liqun Luo
MGI:5816464
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Emx1tm1(cre)Krj/?
Rai1tm2.1Luo/Rai1tm2.1Luo
either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6) MGI:5817664
cn2
Gad2tm2(cre)Zjh/?
Rai1tm2.1Luo/Rai1tm2.1Luo
either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6) MGI:5817645
cn3
Rai1tm2.1Luo/Rai1tm2.1Luo
Slc17a6tm2(cre)Lowl/?
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6) MGI:5817637
cn4
Rai1tm2.1Luo/Rai1+
Slc17a6tm2(cre)Lowl/?
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6) MGI:5817641
cn5
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Gfap-cre)73.12Mvs/?
either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd) MGI:5817666
cn6
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nr5a1-cre)7Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817657
cn7
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Sim1-cre)1Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817650
cn8
Rai1tm2.1Luo/Rai1+
Tg(Sim1-cre)1Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817653
cn9
Rai1tm2.1Luo/Rai1+
Tg(Nr5a1-cre)7Lowl/?
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) MGI:5817661
cn10
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817471
cn11
Rai1tm2.1Luo/Rai1+
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817609
cn12
Rai1tm2.2Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) MGI:5817614


Genotype
MGI:5817664
cn1
Allelic
Composition
Emx1tm1(cre)Krj/?
Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic
Background
either: (involves: 129S1/Sv * 129S2/SvPas * C57BL/6) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit differences in behavior, motor function or body weight from controls




Genotype
MGI:5817645
cn2
Allelic
Composition
Gad2tm2(cre)Zjh/?
Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic
Background
either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased freezing behavior in contextual memory recall
• decreased freezing behavior in cued recall




Genotype
MGI:5817637
cn3
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Slc17a6tm2(cre)Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased freezing behavior in contextual recall in trace fear-conditioning task
• decreased freezing behavior in cued recall
• increased time required to descend in pole test
• increased latency to fall in wire hang test

growth/size/body
• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks




Genotype
MGI:5817641
cn4
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Slc17a6tm2(cre)Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Slc17a6tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased latency to fall in wire hang test

growth/size/body
• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls




Genotype
MGI:5817666
cn5
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Gfap-cre)73.12Mvs/?
Genetic
Background
either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Gfap-cre)73.12Mvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit differences in behavior, motor function or body weight




Genotype
MGI:5817657
cn6
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nr5a1-cre)7Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• males exhibit no motor weakness in wire hang test

growth/size/body
• females are 27% heavier than controls at 20 weeks of age




Genotype
MGI:5817650
cn7
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Sim1-cre)1Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological
N
• males exhibit no motor weakness in wire hang test
• hyperphagic with a 47% increase in average daily food intake
• decreased horizontal locomotor activity

growth/size/body
• mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism




Genotype
MGI:5817653
cn8
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Sim1-cre)1Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females are 12.7% heavier than controls at 20 weeks of age




Genotype
MGI:5817661
cn9
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Nr5a1-cre)7Lowl/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nr5a1-cre)7Lowl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females are 27% heavier than controls at 20 weeks of age




Genotype
MGI:5817471
cn10
Allelic
Composition
Rai1tm2.1Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition
• males have normal hearing and pain responses
• decreased freezing behavior after repeated tone-shock pairings during training
• decreased freezing behavior in contextual recall in trace fear-conditioning task
• decreased freezing behavior in cued recall
• reduced tendency to explore new arm in Y maze
• hindlimb clasping
• in pole test males slip from pole or climb down in a slow and uncoordinated fashion
• decreased latency to fall in wire hang test

growth/size/body
• female mice become overweight beginning at 5 weeks of age
• at 20 weeks female mice are 101% heavier than controls
• mice are smaller than littermates prior to weaning

mortality/aging
• more than 80% of mice die before 25 weeks of age

skeleton
• kyphosis in 10% of mice that die before 10 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Smith-Magenis syndrome DOID:0060768 OMIM:182290
J:237687




Genotype
MGI:5817609
cn11
Allelic
Composition
Rai1tm2.1Luo/Rai1+
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males exhibit a decreased latency to fall in wire hang test

growth/size/body
• female mice become overweight beginning at 7 weeks of age
• at 20 weeks female mice are 35% heavier than controls




Genotype
MGI:5817614
cn12
Allelic
Composition
Rai1tm2.2Luo/Rai1tm2.1Luo
Tg(Nes-cre)1Kln/?
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation (1 available); any Rai1 mutation (73 available)
Rai1tm2.2Luo mutation (0 available); any Rai1 mutation (73 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• female mice become overweight beginning at 7 weeks of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory