Phenotypes associated with this allele

• Allele Symbol: Zfp36l3^tm1Pjb
• Allele Name: targeted mutation 1, Perry J Blackshear
• Allele ID: MGI:5816709
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp36l3^tm1Pjb/Zfp36l3^tm1Pjb	involves: C57BL/6 * C57BL/6NTac	MGI:5898431
ht2	Zfp36l3^tm1Pjb/Zfp36l3^+	involves: C57BL/6 * C57BL/6NTac	MGI:5898432
ot3	Zfp36l3^tm1Pjb/Y	involves: C57BL/6 * C57BL/6NTac	MGI:5898433

Genotype
MGI:5898431

hm1

• Allelic Composition: Zfp36l3^tm1Pjb/Zfp36l3^tm1Pjb
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:230794 )

♀ • females survive at a frequency of 18% compared with the expected 25% rate

♀ • however, surviving females are viable, live to adulthood, and are fertile

prenatal lethality, incomplete penetrance ( J:230794 )

♀ • decrease in the total number of surviving, weaned mutant pups; mice that are born are viable, indicating partial prenatal lethality

homeostasis/metabolism

abnormal iron level ( J:230794 )

♀ • fetuses show about 30% decrease in iron levels at E15.5

abnormal zinc homeostasis ( J:230794 )

♀ • fetuses show 7-10% decrease in zinc levels at E15.5

embryo

embryo phenotype ( J:230794 )

♀N • placentas appear normal

Genotype
MGI:5898432

ht2

• Allelic Composition: Zfp36l3^tm1Pjb/Zfp36l3⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

mortality/aging

decreased survivor rate ( J:230794 )

♀ • heterozygous females survive at a frequency of 19% compared with the expected 25% rate

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:230794 )

♀ • fewer than the expected numbers of surviving heterozygous females is seen suggesting that X inactivation of the single allele present occurs

paternal imprinting ( J:230794 )

♀ • when the mutant allele comes from the female, the paternal wild-type allele is inactivated, indicating paternal imprinting

Genotype
MGI:5898433

ot3

• Allelic Composition: Zfp36l3^tm1Pjb/Y
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

mortality/aging

decreased survivor rate ( J:230794 )

♂ • males survive at a frequency of 14%-16% compared with the expected 25% rate

♂ • however, males that are born alive are viable, live to adulthood and are fertile

lethality throughout fetal growth and development, incomplete penetrance ( J:230794 )

♂ • viable male embryos are present at 28% at E15.5 compared with the expected 25%, indicating that the lethality occurs after E15.5

homeostasis/metabolism

abnormal iron level ( J:230794 )

♂ • fetuses show about 30% decrease in iron levels at E15.5

abnormal zinc homeostasis ( J:230794 )

♂ • fetuses show 7-10% decrease in zinc levels at E15.5