Analysis Tools
cellular
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• increased mitochondrial proton leak in pancreatic islets under stimulatory (20 mM glucose), but not basal, conditions
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• MEFs have lower levels of cellular superoxide and hydrogen peroxide
• following hydrogen peroxide exposure, MEFs exhibit a diminished ability to amplify ROS
• intact pancreatic islets have a 60% decrease in basal superoxide content as compared to control
• dispersed islets have lower ROS under both basal and stimulatory conditions as compared to control
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endocrine/exocrine glands
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• pancreatic islets have a 51% increase in glucose-stimulated insulin secretion
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homeostasis/metabolism
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• pancreatic islets have a 51% increase in glucose-stimulated insulin secretion
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• mice treated with STZ are hyperglycemic but to a lower level than STZ-treated controls
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• increase in basal and maximal respiration at 20 mM glucose, however oxygen consumption rate is similar to control under basal conditions
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• enhanced glucose tolerance with lower peak glucose excursion and decreased area under the curve (AUC)
• however, response to the insulin tolerance test is similar to control
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