Analysis Tools
behavior/neurological
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• mice show mildly increased anxiety-like behavior in the light-dark test
• however, mice show normal behavior in the elevated plus maze and in the center region of the open-field arena
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• mice show impaired motor coordination in the Erasmus ladder test
• however, mice do not show any abnormalities in social interaction, social novelty recognition, ultrasonic vocalization, repetitive behaviors (self-grooming, jumping, digging, and marble burying), in the rotarod test, and open-field behavior and show normal visual and olfactory function
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• mice show increased repetitive behavior in the hole-board test
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nervous system
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• reduction in levels of excitatory synaptic protein (GluD2 and PSD-93) levels in the cerebellum
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• Purkinje cells show miniature excitatory postsynaptic currents (mEPSCs) with reduced frequency but normal amplitude
• however, mice show normal LTD at parallel fibers-Purkinje cell synapses in the cerebellum
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