All Phenotypes Prdx6<tm2Abf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prdx6^tm2Abf
targeted mutation 2, Aron B Fisher
MGI:5817017

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdx6^tm2Abf/Prdx6^tm2Abf	involves: C57BL/6J	MGI:5817018

Allelic Composition	Prdx6^tm2Abf/Prdx6^tm2Abf
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdx6^tm2Abf mutation (0 available); any Prdx6 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal phospholipid level ( J:237406 )

respiratory system

abnormal surfactant physiology ( J:237406 )

• increase in levels of total phospholipid, disaturated phosphatidylcholine (DSPC), and phosphatidylcholine (PC) in lung tissue, lung lavage fluid and lamellar bodies

• degradation of depalmitoylphosphatidylcholine (DPPC) in the lungs is decreased as compared to wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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