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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il22ra1tm1.1Koll
targeted mutation 1.1, Jay K Kolls
MGI:5817816
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Eportm1.1(EGFP/icre)Uk/Epor+
involves: BALB/cJ * C57BL/6 MGI:6712738
cn2
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:6712737


Genotype
MGI:6712738
cn1
Allelic
Composition
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Eportm1.1(EGFP/icre)Uk/Epor+
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (27 available)
Il22ra1tm1.1Koll mutation (1 available); any Il22ra1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in RIII and RIV erythroid precursors in the bone marrow compared to controls
• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in peripheral blood red blood cell numbers compared to controls
• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in hematocrit compared to controls

homeostasis/metabolism
• mice show alleviation of stress-induced anemia, showing increased peripheral blood cell counts, increased hematocrit, and increase in erythroid precursors in the bone marrow following phenylhydrazine-induced stress erythropoiesis




Genotype
MGI:6712737
cn2
Allelic
Composition
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Il22ra1tm1.1Koll mutation (1 available); any Il22ra1 mutation (31 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice show an improvement in peripheral blood red blood cell numbers and hematocrit levels, and an increase in RIII and RIV erythroid precursors in the bone marrow compared to Il22ra1-sufficient Riok2-haploinsufficent mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory