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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hlcsem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5817955
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hlcsem1(IMPC)J/Hlcsem1(IMPC)J C57BL/6NJ-Hlcsem1(IMPC)J/Mmjax MGI:6262627
ht2
 		Hlcsem1(IMPC)J/Hlcs+ C57BL/6NJ-Hlcsem1(IMPC)J/Mmjax MGI:7317001


Genotype
MGI:6262627
hm1
Allelic
Composition		 Hlcsem1(IMPC)J/Hlcsem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Hlcsem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hlcsem1(IMPC)J mutation (2 available); any Hlcs mutation (43 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hlcsem1(IMPC)J/Hlcsem1(IMPC)J mice exhibit embryonic lethality. Embryos are recovered at E7.5 but arrest prior to gastrulation and no embryos are seen at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or gastrulation are seen at E7.5.

embryo
failure to gastrulate ( J:290315 , J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)
embryonic growth arrest ( J:279207 )
• embryos arrest prior to gastrulation
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
decreased egg cylinder size ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5




Genotype
MGI:7317001
ht2
Allelic
Composition		 Hlcsem1(IMPC)J/Hlcs+
Genetic
Background		 C57BL/6NJ-Hlcsem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hlcsem1(IMPC)J mutation (2 available); any Hlcs mutation (43 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

homeostasis/metabolism

integument

pigmentation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory