Phenotypes associated with this allele

• Allele Symbol: Begain^tm1.1Tayk
• Allele Name: targeted mutation 1.1, Tayo Katano
• Allele ID: MGI:5818151
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Begain^tm1.1Tayk/Begain^tm1.1Tayk	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7709172

Genotype
MGI:7709172

hm1

• Allelic Composition: Begain^tm1.1Tayk/Begain^tm1.1Tayk
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:237768 )

• shapes of NMDAR EPSCs are abnormal with relatively slower developing currents and an abnormal rising phase

prolonged excitatory postsynaptic current rise time ( J:237768 )

• increased time to peak of NMDAR EPSCs but not of AMPAR EPSCs

• delay between times to peak of AMPAR and NMDAR EPSCs is longer than in wild-type singe substantia gelatinosa neurons

behavior/neurological

abnormal long-term spatial reference memory ( J:352512 )

• impaired performance in a Barnes maze

fast extinction of fear memory ( J:352512 )

• no difference in freezing time at 1 day after conditioning but by 28 days freezing time is reduced compared to wild-type controls

abnormal pain threshold ( J:237768 )

• 3 days following spared nerve injury, mechanical pain threshold is reduced but not as much as in similarly treated wild-type mice