Phenotypes associated with this allele

• Allele Symbol: Hnrnpa1^tm1.1Cyf
• Allele Name: targeted mutation 1.1, Yung-Fu Chang
• Allele ID: MGI:5818661
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hnrnpa1^tm1.1Cyf/Hnrnpa1^tm1.1Cyf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl	MGI:5818673
ht2	Hnrnpa1^tm1.1Cyf/Hnrnpa1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl	MGI:5818674

Genotype
MGI:5818673

hm1

• Allelic Composition: Hnrnpa1^tm1.1Cyf/Hnrnpa1^tm1.1Cyf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:238260 )

• newborn mice die within 30 minutes of birth

prenatal lethality, incomplete penetrance ( J:238260 )

• fewer than expected mice are born

muscle

dilated cardiomyopathy ( J:238260 )

abnormal tongue muscle morphology ( J:238260 )

• irregular and hypoplastic with fibrous tissue infiltration

tongue muscle hypoplasia ( J:238260 )

abnormal intercostal muscle morphology ( J:238260 )

• degeneration and hypoplasia

digestive/alimentary system

abnormal tongue muscle morphology ( J:238260 )

• irregular and hypoplastic with fibrous tissue infiltration

tongue muscle hypoplasia ( J:238260 )

growth/size/body

abnormal tongue muscle morphology ( J:238260 )

• irregular and hypoplastic with fibrous tissue infiltration

tongue muscle hypoplasia ( J:238260 )

decreased body length ( J:238260 )

cardiovascular system

dilated heart ventricle ( J:238260 )

dilated cardiomyopathy ( J:238260 )

renal/urinary system

abnormal urinary bladder morphology ( J:238260 )

• with hyperplasia in the transitional cells

craniofacial

abnormal tongue muscle morphology ( J:238260 )

• irregular and hypoplastic with fibrous tissue infiltration

tongue muscle hypoplasia ( J:238260 )

Genotype
MGI:5818674

ht2

• Allelic Composition: Hnrnpa1^tm1.1Cyf/Hnrnpa1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JNarl

cardiovascular system

increased heart rate ( J:238260 )

shortened PR interval ( J:238260 )

abnormal P wave ( J:238260 )

• reduced duration

increased systemic arterial systolic blood pressure ( J:238260 )