Phenotypes associated with this allele

• Allele Symbol: Cd276^tm1Lpc
• Allele Name: targeted mutation 1, Lieping Chen
• Allele ID: MGI:5818965
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd276^tm1Lpc/Cd276^tm1Lpc	B6.129-Cd276^tm1Lpc	MGI:5818967
hm2	Cd276^tm1Lpc/Cd276^tm1Lpc	D1J.129-Cd276^tm1Lpc	MGI:5818970

Genotype
MGI:5818967

hm1

• Allelic Composition: Cd276^tm1Lpc/Cd276^tm1Lpc
• Genetic Background: B6.129-Cd276^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enhanced airway allergic responses in Cd276^tm1Lpc/Cd276^tm1Lpc mice

immune system

abnormal T-helper 1 physiology ( J:237700 )

• myelin-specific T cell response is reduced in response to MOG 33-35 peptide, with draining lymph nodes producing less IFN-gamma, IL-12, and IL-17, and generating a decreased proportion of IFN-gamma producing cells under Th1 polarizing conditions

abnormal T-helper 2 physiology ( J:237700 )

• mice show enhanced Th2-mediated allergic responses in the airway

• splenocytes from OVA-immunized mice re-challenged with OVA protein in vitro exhibit increased proliferation compared to wild-type cells

• when stimulated with OVA protein under Th2 polarizing conditions, splenocytes induce a larger proportion of IL-4 producing cells than from wild-type cells

increased susceptibility to type I hypersensitivity reaction ( J:237700 )

• mice immunized with injection of OVA-aluminum and challenged with aerosolized OVA protein exhibit higher total bronchoalveolar lavage fluid (BALF) cell counts, mainly in eosinophils, increased inflammation and mucus production, increase in IL-5 and IL-13 production in BALF, and an increase in OVA-specific IgE, indicating enhanced Th2-mediated allergic responses in the airway

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:237700 )

• mice are more resistant to experimental autoimmune encephalitis, showing attenuated symptoms during the course of disease development and partial recovery from symptoms even though disease incidence is 100%

• mice show fewer inflammatory cells in the proximal spinal cord

hematopoietic system

abnormal T-helper 1 physiology ( J:237700 )

• myelin-specific T cell response is reduced in response to MOG 33-35 peptide, with draining lymph nodes producing less IFN-gamma, IL-12, and IL-17, and generating a decreased proportion of IFN-gamma producing cells under Th1 polarizing conditions

abnormal T-helper 2 physiology ( J:237700 )

• mice show enhanced Th2-mediated allergic responses in the airway

• splenocytes from OVA-immunized mice re-challenged with OVA protein in vitro exhibit increased proliferation compared to wild-type cells

• when stimulated with OVA protein under Th2 polarizing conditions, splenocytes induce a larger proportion of IL-4 producing cells than from wild-type cells

Genotype
MGI:5818970

hm2

• Allelic Composition: Cd276^tm1Lpc/Cd276^tm1Lpc
• Genetic Background: D1J.129-Cd276^tm1Lpc

Cd276^tm1Lpc/Cd276^tm1Lpc mice are resistant to collagen-induced arthritis

immune system

abnormal T-helper 1 physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

abnormal T-helper 17 cell physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

decreased susceptibility to induced arthritis ( J:237700 )

• mice exhibit decreased severity of collagen-induced arthritis, showing a later onset, an attenuated severity of arthritis, decreased severity in joint swelling, and lower levels of collagen II-specific IgG

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

hematopoietic system

abnormal T-helper 1 physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

abnormal T-helper 17 cell physiology ( J:237700 )

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed

skeleton

decreased susceptibility to induced arthritis ( J:237700 )

• mice exhibit decreased severity of collagen-induced arthritis, showing a later onset, an attenuated severity of arthritis, decreased severity in joint swelling, and lower levels of collagen II-specific IgG

• collagen II specific T cell proliferation and cytokine (IFN-gamma, IL-2, IL-6, TNF, and IL-17) production are reduced in splenocytes isolated from mice with collagen-induced arthritis, suggesting that Th1, Th17, and B cell responses are suppressed