Phenotypes associated with this allele

• Allele Symbol: Crh^tm2.1Maj
• Allele Name: targeted mutation 2.1, Joseph Majzoub
• Allele ID: MGI:5819101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Crh^tm2.1Maj/Crh^tm2.1Maj Tg(Sim1-cre)1Lowl/?	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5823206

Genotype
MGI:5823206

cn1

• Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj; Tg(Sim1-cre)1Lowl/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:238330 )

• mice spend increased time in center in open-field paradigm

• mice exhibit a shorter latency into both center and neutral areas in open-field paradigm

• entry into center of holeboard is increased

• increase in exploratory tendency and risky behavior in a new environment

• mice spend less time in closed arms and increased time in open arms of elevated plus maze

• mice exhibit a decreased latency to enter lit arms of light-dark box

• mice exhibit a preference for approaching a novel versus familiar object

• mice exhibit a longer exploratory duration around a novel object

endocrine/exocrine glands

decreased adrenal gland weight ( J:238330 )

adrenal gland atrophy ( J:238330 )

• adrenal atrophy especially in the zone fasciculata of the adrenal gland

abnormal adrenal gland secretion ( J:238330 )

• stress-induced plasma corticosterone release is two-thirds of controls

homeostasis/metabolism

decreased circulating corticosterone level ( J:238330 )

• decreased basal, diurnal, and stressor-stimulated plasma corticosterone secretion

decreased circulating adrenocorticotropin level ( J:238330 )

• decreased plasma adrenocorticotropic hormone