mortality/aging
• following exposure to 5 Gy of whole-body gamma radiation, mice (>12 weeks of age) show significantly increased lethality relative to wild-type controls, although this is not as dramatic as that observed in Atmtm1Awb homozygotes
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immune system
N |
• mice show no overt immunodeficiency and mount a normal humoral response upon immunization with purified fragment C of tetanus toxin relative to wild-type controls
• no defects in class switch recombination are observed
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• mice exhibit a small increase in the number and percentage of mature B cells in the bone marrow
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• significant reduction of B cell number in spleen
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• mild reduction of transitional B cell number in spleen
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• significant reduction of follicular B cell number in spleen
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• significant reduction of T cell number in spleen
• however, T cell development in the thymus is normal
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• significant reduction of CD4+ T cell number in spleen
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• mild reduction of CD8+ T cell number in spleen
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• mice show a significant reduction of total cell numbers in the spleen, but not in the thymus or bone marrow, relative to wild-type controls
• splenic cell reduction is mainly due to decreased B cell and T cell populations
• however, splenic marginal zone B cell numbers and NK cell numbers are normal
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hematopoietic system
• mice exhibit a small increase in the number and percentage of mature B cells in the bone marrow
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• significant reduction of B cell number in spleen
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• mild reduction of transitional B cell number in spleen
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• significant reduction of follicular B cell number in spleen
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• significant reduction of T cell number in spleen
• however, T cell development in the thymus is normal
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• significant reduction of CD4+ T cell number in spleen
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• mild reduction of CD8+ T cell number in spleen
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• mice show a significant reduction of total cell numbers in the spleen, but not in the thymus or bone marrow, relative to wild-type controls
• splenic cell reduction is mainly due to decreased B cell and T cell populations
• however, splenic marginal zone B cell numbers and NK cell numbers are normal
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homeostasis/metabolism
• following exposure to 5 Gy of whole-body gamma radiation, mice (>12 weeks of age) show significantly increased lethality relative to wild-type controls, although this is not as dramatic as that observed in Atmtm1Awb homozygotes
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cellular
N |
• mice show no increased genomic instability, as determined by micronucleus formation
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neoplasm