Phenotypes associated with this allele

• Allele Symbol: Crh^tm2.2Maj
• Allele Name: targeted mutation 2.2, Joseph Majzoub
• Allele ID: MGI:5823156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crh^tm2.2Maj/Crh^tm2.2Maj	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5823207

Genotype
MGI:5823207

hm1

• Allelic Composition: Crh^tm2.2Maj/Crh^tm2.2Maj
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal effect ( J:238330 )

• offspring of homozygous mothers die within several hours of birth due lung dysplasia, marked hypercellularity of lungs, increased alveolar thickness, paucity of air space

• administration of corticosterone to mothers reverses death and lung pathology in neonates

endocrine/exocrine glands

adrenal gland atrophy ( J:238330 )

• atrophy of zone fasciculata of the adrenal gland

abnormal adrenal gland secretion ( J:238330 )

• reduced glucocorticoid release under stress (restraint challenge) as compared to controls

homeostasis/metabolism

decreased circulating corticosterone level ( J:238330 )

• reduced basal plasma corticosterone level as compared to controls