Analysis Tools
reproductive system
azoospermia
(
J:238491
)
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• absence of postmeiotic cell types
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• failure of synapsis formation and arrest in a pachytene-like stage
• complete desynapsis but with the full integrity of axial elements
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• impaired processing of recombination intermediates into chiasmata
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• in a subset of meiocytes poorly aligned or unaligned chromosome pairs are detected
• misaligned chromosomes are more frequently seen in oocytes compared to spermatocytes
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|
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• absence of postmeiotic cell types
|
|
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• X-Y chromosome alignment occurs in only 25.49 +/- 0.06% of cells
• in spermatocytes lacking X-Y alignment the sex body is not formed
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• arrest at stage IV at which point there is massive apoptosis of spermatocytes
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|
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• arrest at stage IV at which point there is massive apoptosis of spermatocytes
• extensive apoptosis of spermatocytes is detected at 18 days of age during the first wave of meiosis
|
 |
• absence of oogenesis
|
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• at 4 months of age
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• dense stroma at 4 months of age
• severe ovarian dysgenesis at 6 days of age
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• at 6 days of age follicle numbers are reduced
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• lack postmeiotic cell types
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small testis
(
J:238491
)
|
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• testes size is 30% of wild-type
|
endocrine/exocrine glands
|
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• dense stroma at 4 months of age
• severe ovarian dysgenesis at 6 days of age
|
|
|
• at 6 days of age follicle numbers are reduced
|
|
|
• lack postmeiotic cell types
|
small testis
(
J:238491
)
|
|
• testes size is 30% of wild-type
|
cellular
azoospermia
(
J:238491
)
|
|
• absence of postmeiotic cell types
|
|
• failure of synapsis formation and arrest in a pachytene-like stage
• complete desynapsis but with the full integrity of axial elements
|
|
• impaired processing of recombination intermediates into chiasmata
|
|
• in a subset of meiocytes poorly aligned or unaligned chromosome pairs are detected
• misaligned chromosomes are more frequently seen in oocytes compared to spermatocytes
|
|
|
• absence of postmeiotic cell types
|
|
|
• X-Y chromosome alignment occurs in only 25.49 +/- 0.06% of cells
• in spermatocytes lacking X-Y alignment the sex body is not formed
|
|
|
• arrest at stage IV at which point there is massive apoptosis of spermatocytes
|
|
|
• arrest at stage IV at which point there is massive apoptosis of spermatocytes
• extensive apoptosis of spermatocytes is detected at 18 days of age during the first wave of meiosis
|
|
|
• absence of oogenesis
|
|
|
• at 4 months of age
|
