Phenotypes associated with this allele

• Allele Symbol: Aim2^tm1.2Arte
• Allele Name: targeted mutation 1.2, TaconicArtemis
• Allele ID: MGI:5823433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Aim2^tm1.2Arte/Aim2^tm1.2Arte Dnase2a^tm1Osa/Dnase2a^tm1Osa Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129 * BALB/c * C57BL/6 * C57BL/6J	MGI:5823437

Genotype
MGI:5823437

cx1

• Allelic Composition: Aim2^tm1.2Arte/Aim2^tm1.2Arte; Dnase2a^tm1Osa/Dnase2a^tm1Osa; Ifnar1^tm1Agt/Ifnar1^tm1Agt
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal spleen morphology ( J:238323 )

• increase in expression of IFN-beta in splenic tissue

enlarged spleen ( J:238323 )

• splenomegaly, with spleen sizes being 4-5 fold increased

increased spleen weight ( J:238323 )

homeostasis/metabolism

increased circulating interleukin-10 level ( J:238323 )

increased circulating tumor necrosis factor level ( J:238323 )

immune system

abnormal spleen morphology ( J:238323 )

• increase in expression of IFN-beta in splenic tissue

enlarged spleen ( J:238323 )

• splenomegaly, with spleen sizes being 4-5 fold increased

increased spleen weight ( J:238323 )

increased circulating interleukin-10 level ( J:238323 )

increased circulating tumor necrosis factor level ( J:238323 )

increased autoantibody level ( J:238323 )

• presence of anti-cyclic citrullinated peptide antibodies

rheumatoid arthritis ( J:238323 )

• signs of polyarthritis are reduced compared to double Dnase2a and Ifnar1 homozygotes, although mice do show some arthritis development

• joints do not show an increase in cleaved caspase-1

• expression of pro-inflammatory cytokines, such as TNF, IL-6, and IL-1beta, is reduced both at protein and mRNA level in joints compared to double Dnase2a and Ifnar1 homozygotes

• mice show decreased macrophage infiltration in joints compared to double Dnase2a and Ifnar1 homozygotes

skeleton

rheumatoid arthritis ( J:238323 )

• signs of polyarthritis are reduced compared to double Dnase2a and Ifnar1 homozygotes, although mice do show some arthritis development

• joints do not show an increase in cleaved caspase-1

• expression of pro-inflammatory cytokines, such as TNF, IL-6, and IL-1beta, is reduced both at protein and mRNA level in joints compared to double Dnase2a and Ifnar1 homozygotes

• mice show decreased macrophage infiltration in joints compared to double Dnase2a and Ifnar1 homozygotes

growth/size/body

enlarged spleen ( J:238323 )

• splenomegaly, with spleen sizes being 4-5 fold increased

increased spleen weight ( J:238323 )