Phenotypes associated with this allele

• Allele Symbol: Tg(Mpz*S63C)32Mes
• Allele Name: transgene insertion 32, Albee Messing
• Allele ID: MGI:5824059
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Mpz*S63C)32Mes/0	involves: FVB/N	MGI:6276568

Genotype
MGI:6276568

tg1

• Allelic Composition: Tg(Mpz*S63C)32Mes/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:105751 )

ataxia ( J:105751 )

weakness ( J:105751 )

muscle

muscular atrophy ( J:105751 )

• muscle atrophy in the hindlimbs

nervous system

abnormal nervous system physiology ( J:105751 )

• mice develop a neuromuscular disorder between 4-8 weeks of age

demyelination ( J:105751 )

• sciatic nerve shows demyelinating neuropathy

• onion bulbs, signifying myelin destruction followed by attempts to remyelinate, are present at 6 months of age and increase in number with age

dysmyelination ( J:105751 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease type 3		DOID:0050540	OMIM:145900	J:105751