Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Mpz*S63C)33Mes transgene insertion 33, Albee Messing MGI:5824061 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit compacted sheaths with a regular periodic structure like wild-type mice, however, the periodicity is expanded by 21%; majority of this increase derives from the extracellular space
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myelin contains disordered packing of membranes and shows a swollen phase that increases to about 40% of the total by 7 hours in x-ray diffraction analysis
• however, myelin does not show altered period or altered intermembrane distances
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• total myelin diffraction is reduced by about half, indicative of both hypomyelination and demyelination
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• total myelin diffraction is reduced by about half, indicative of both hypomyelination and demyelination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• muscle atrophy in the hindlimbs
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• myelin contains disordered packing of membranes
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• mice develop a neuromuscular disorder between 4-8 weeks of age
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• sciatic nerve shows demyelinating neuropathy
• onion bulbs, signifying myelin destruction followed by attempts to remyelinate, are present at 6 months of age and increase in number with age
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• hypomyelination with occasional nude axons
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Charcot-Marie-Tooth disease type 3 | DOID:0050540 |
OMIM:145900 |
J:105751 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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