Phenotypes associated with this allele

• Allele Symbol: Mpz^tm1.1Wra
• Allele Name: targeted mutation 1.1, Lawrence Wrabetz
• Allele ID: MGI:5824069
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpz^tm1.1Wra/Mpz^tm1.1Wra	FVB.129S2-Mpz^tm1.1Wra	MGI:6273182
ht2	Mpz^tm1.1Wra/Mpz^+	FVB.129S2-Mpz^tm1.1Wra	MGI:6273176

Genotype
MGI:6273182

hm1

• Allelic Composition: Mpz^tm1.1Wra/Mpz^tm1.1Wra
• Genetic Background: FVB.129S2-Mpz^tm1.1Wra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

dysmyelination ( J:267903 )

• mice exhibit severe hypomyelination of sciatic nerves at P10

Genotype
MGI:6273176

ht2

• Allelic Composition: Mpz^tm1.1Wra/Mpz⁺
• Genetic Background: FVB.129S2-Mpz^tm1.1Wra

behavior/neurological

impaired coordination ( J:267903 )

• P10-P12 mice show a reduction in motor coordination on the rotarod, however this defect is no longer present in adult P28 mice

• P10-P12 mice show a higher number of errors on the grid walking test, however this defect is no longer present in adult P28 mice

nervous system

abnormal axon radial sorting ( J:267903 )

• mice show an increase of bundles of unsorted mixed caliber axons in nerves at P11 that are not seen in wild-type nerves, however by P14, the radial sorting defect is no longer visible, indicating a delay in myelination

dysmyelination ( J:267903 )

• P28 sciatic nerves show a mild hypomyelination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuropathy		DOID:870		J:267903