Analysis Tools
adipose tissue
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• P7 interscapular brown adipose tissue depots are heavier as a proportion of body weight by 60%
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• interscapular brown adipose tissue depots show increased cellularity
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• retroperitoneal white adipose tissue shows an abundance of smaller adipocytes with a multilocular appearance
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• P7 interscapular brown fat depots show increased cellularity and mitochondrial DNA content
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• P7 interscapular brown adipose tissue depots are heavier as a proportion of body weight by 60%
|
|
• reduction in weight of mesenteric, inguinal, and retroperitoneal white adipose tissue depots relative to total body weight
|
behavior/neurological
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• mice consume significantly less standard chow than wild-type mice
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growth/size/body
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• newborns are lighter
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• males and females are lighter at 10 weeks of age
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• fetuses are lighter at E18.5
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homeostasis/metabolism
hypoglycemia
(
J:232408
)
|
• hypoglycemia in the fed state
|
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• basal body temperature is elevated
|
nervous system
|
• increase in brain weight/body weight ratio in newborns
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Silver-Russell syndrome | DOID:14681 |
OMIM:180860 |
J:232408 | |
