Analysis Tools
behavior/neurological
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• lick cluster size analysis to measure perceived palatability shows that mice have a smaller average lick cluster sizes while total number of licks and total number of bouts are similar to wild-type and no difference in overall consumption of the solution or inter lick interval are seen, indicating that mutants perceive a lower palatability of a sucrose solution
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• mice are hypoactive, making nearly half as many runs in any given session as controls
• hypoactivity is not related to impaired motoric function as mice exhibit normal behavior on the rotarod
• however, emotional reactivity and anxiety are not altered, with mice showing normal behavior in the elevated plus maze test and the open field test
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hearing/vestibular/ear
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• general hearing impairment
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nervous system
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• increase in tyrosine hydroxylase+ cells in the periventricular hypothalamus
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• impaired sensorimotor gating response
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• prepulse inhibition of the acoustic startle response is attenuated by almost half, with further inhibition with increasing prepulse
• however, no difference in acoustic startle response at 105 dB
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Silver-Russell syndrome | DOID:14681 |
OMIM:180860 |
J:239325 | |
