Phenotypes associated with this allele

• Allele Symbol: Spp1^tm1.1Dhd
• Allele Name: targeted mutation 1.1, Dick Heinegard
• Allele ID: MGI:5825176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spp1^tm1.1Dhd/Spp1^tm1.1Dhd	involves: 129P2/OlaHsd * C57BL/6	MGI:5825177

Genotype
MGI:5825177

hm1

• Allelic Composition: Spp1^tm1.1Dhd/Spp1^tm1.1Dhd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoclast cell number ( J:237104 )

• 2- to 3-fold higher volume in the lower metaphysis

• 2-fold increase in the number of osteoclasts

abnormal osteoclast physiology ( J:237104 )

• reduced volume and length of osteoclast ruffled borders indicating lower resorptive capacity

abnormal long bone metaphysis morphology ( J:237104 )

♀ • absence of age-dependent loss of metaphyseal bone volume in older female mice

hematopoietic system

abnormal macrophage morphology ( J:237104 )

• slightly enlarged

decreased osteoclast cell number ( J:237104 )

• 2- to 3-fold higher volume in the lower metaphysis

• 2-fold increase in the number of osteoclasts

abnormal osteoclast physiology ( J:237104 )

• reduced volume and length of osteoclast ruffled borders indicating lower resorptive capacity

immune system

abnormal macrophage morphology ( J:237104 )

• slightly enlarged

decreased osteoclast cell number ( J:237104 )

• 2- to 3-fold higher volume in the lower metaphysis

• 2-fold increase in the number of osteoclasts

abnormal osteoclast physiology ( J:237104 )

• reduced volume and length of osteoclast ruffled borders indicating lower resorptive capacity