Phenotypes associated with this allele

• Allele Symbol: Pcdh9^tm1Mjhk
• Allele Name: targeted mutation 1, Martien J Kas
• Allele ID: MGI:5825237
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcdh9^tm1Mjhk/Pcdh9^tm1Mjhk	B6.Cg-Pcdh9^tm1Mjhk	MGI:5825246
ht2	Pcdh9^tm1Mjhk/Pcdh9^+	B6.Cg-Pcdh9^tm1Mjhk	MGI:5825247

Genotype
MGI:5825246

hm1

• Allelic Composition: Pcdh9^tm1Mjhk/Pcdh9^tm1Mjhk
• Genetic Background: B6.Cg-Pcdh9^tm1Mjhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237757 )

N • mice exhibit normal social approach, response to social novelty, anxiety-like behavior, multi-trial associative learning, fear acquisition and consolidation and startle response

impaired long-term object recognition memory ( J:237757 )

• following long-term intertrial intervals (ITI), mice exhibit impaired novel object recognition (NORE) capacity compared with wild-type mice

• however, NORE capacity is normal following a short-term ITI

impaired coordination ( J:237757 )

• reduced latency to fall on a rotarod from 6 weeks of age

increased locomotor activity ( J:237757 )

• increased activity, velocity and distance moved in pre-adult mice

• however, adult mice exhibit normal activity

abnormal sensory capabilities/reflexes/nociception ( J:237757 )

• reduced touch-evoked biting

abnormal social recognition ( J:237757 )

• following long-term intertrial intervals (ITI), mice exhibit impaired social recognition (SRE) compared with wild-type mice

• however, SRE is normal following a short-term ITI

nervous system

nervous system phenotype ( J:237757 )

N • mice exhibit normal motor cortex layer thickness and cell number

thin cerebral cortex ( J:237757 )

• in deeper layers

abnormal dendrite morphology ( J:237757 )

• mice exhibit reduced total apical dendrite length, surface and number of intersections compared with wild-type mice

increased dendritic spine number ( J:237757 )

• increased spine number of the primary branch of apical dendrites

decreased neuron number ( J:237757 )

• in deeper layers of the cortex

decreased prepulse inhibition ( J:237757 )

Genotype
MGI:5825247

ht2

• Allelic Composition: Pcdh9^tm1Mjhk/Pcdh9⁺
• Genetic Background: B6.Cg-Pcdh9^tm1Mjhk

behavior/neurological

behavior/neurological phenotype ( J:237757 )

N • mice exhibit normal novel object recognition after short- or long-term intertrial intervals

abnormal social recognition ( J:237757 )

• following long-term intertrial intervals (ITI), mice exhibit impaired social recognition (SRE) compared with wild-type mice

• however, SRE is normal following a short-term ITI

nervous system

nervous system phenotype ( J:237757 )

N • mice exhibit normal motor cortex layer thickness and cell number

thin cerebral cortex ( J:237757 )

• in deeper layers

abnormal dendrite morphology ( J:237757 )

• mice exhibit reduced total apical dendrite length, surface and number of intersections compared with wild-type mice

decreased neuron number ( J:237757 )

• in deeper layers of the cortex