Phenotypes associated with this allele

• Allele Symbol: Fxn^em2.1Lutzy
• Allele Name: endonuclease-mediated mutation 2.1, Cathy Lutz
• Allele ID: MGI:5825278
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fxn^em2Lutzy/Fxn^em2.1Lutzy Tg(Ckmm-cre)5Khn/?	B6.Cg-Fxn^em2Lutzy Fxn^em2.1Lutzy Tg(Ckmm-cre)5Khn/J	MGI:5827807

Genotype
MGI:5827807

cn1

• Allelic Composition: Fxn^em2Lutzy/Fxn^em2.1Lutzy; Tg(Ckmm-cre)5Khn/?
• Genetic Background: B6.Cg-Fxn^em2Lutzy Fxn^em2.1Lutzy Tg(Ckmm-cre)5Khn/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart left ventricle weight ( J:101977 )

• left ventricular mass is increased as compared to controls by 9 weeks of age

decreased cardiac muscle contractility ( J:101977 )

• decreased ejection fraction as compared to controls by 7 weeks of age

• decreased fractional shortening as compared to controls by 7 weeks of age

decreased heart rate ( J:101977 )

• decreased heart rate by 7 weeks of age

cardiomyopathy ( J:101977 )

• progressive cardiomyopathy

mortality/aging

premature death ( J:101977 )

• mean survival is 86 +/- days of age

muscle

decreased cardiac muscle contractility ( J:101977 )

• decreased ejection fraction as compared to controls by 7 weeks of age

• decreased fractional shortening as compared to controls by 7 weeks of age

cardiomyopathy ( J:101977 )

• progressive cardiomyopathy